Global Mass Spectrometry Imaging Market By Product Type (Maldi, Esi, Others), By Application (Proteomics, Clinical, Metabolomics, Others), By Region and Key Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends and Forecast 2021-2030 (Includes Business Impact of COVID-19)

                                          
Report updated on 11th September, 2021: Global Mass Spectrometry Imaging Market By Product Type (Maldi, Esi, Others), By Application (Proteomics, Clinical, Metabolomics, Others), By Region and Key Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends and Forecast 2021-2030 (Includes Business Impact of COVID-19)
Trusted Business Insights has published a comprehensive market research report on, Global Mass Spectrometry Imaging Market by Product Type (MALDI, ESI, Others), By Application (Proteomics, Clinical, Metabolomics, Others), and by Region -Global Forecast to 2030, which offers a holistic view of the global mass spectrometry imaging market through systematic segmentation that covers every aspect of the target market.

The global mass spectrometry imaging market is projected to be US$ 707.11 Mn in 2020 to reach US$ 1351.04 Mn by 2030 at a CAGR of 6.7%.

Mass spectrometry imaging (MSI) is an imaging technique that facilitates untargeted investigations of the spatial distribution of molecular species in a variety of samples. It has the feature to image thousands of biological molecules in a single experiment without labelling. The information gathered from mass spectrometry (MS), and visualization of spatial distributions in sample sections makes this a valuable tool useful for biological specimen characterization. The mass spectrometer ionizes the molecules on the surface of the sample and gathers a mass spectrum at each pixel on the section, with the resulting spatial resolution defined by the pixel size. After assembling the spectra, computer software can be used to select an individual mass-to-charge (m/z) value and the intensity of the m/z is extracted from each pixels spectrum. Then these intensities are combined into a heat map image representing the relative distribution of that m/z value throughout the samples surface. To determine the identity of a specific m/z value, Tandem MS fragmentation can be done on ions from each pixel, and the fragments can be used to assemble the structure of the unknown molecule.

Safety Regulations-Strict safety regulations are expected to drive the acceptance of mass spectrometry in the pharmaceuticals, biotechnology and food & beverages testing companies, which is a one of the major factor expected to drive the growth of the market.

However, high cost of mass spectrometry imaging instruments has not only constrained the entry of new and small companies in the market, but have also obstructed leading players from undertaking large-scale research and development activities, which is expected to challenge to the market growth to a certain extent Nonetheless, developing economies in Asia Pacific such as China, India, etc. are relatively untapped market, that provides lucrative opportunities for major players to increase penetration in these markets to augment their market share.


Global Mass Spectrometry Imaging Market Revenue (US$ Mn), 2021 to 2030


Global mass spectrometry imaging market is segmented based on product type, application and region. On the basis of product type, the market is segmented into MALDI, ESI and Others. The MALDI segment accounts for the majority share and is expected to register the highest growth over the forecast period, followed by ESI segment. On the basis of application, the market is segmented into proteomics, clinical, metabolomics and others. The clinical segment accounts for a majority share in the global mass spectrometry imaging market.


Global Mass Spectrometry Imaging Market by Formulation, 2018


On the basis of region, the market is segmented into North America, Europe, APAC, South America and Middle East Africa. North America accounts for the majority share in the global mass spectrometry imaging market, owing to increasing spending on pharmaceuticals R&D. APAC is expected to register the highest growth rate over the forecast period. Regions such as Europe, South America and MEA are expected to register stable growth over the forecast period.

The research report on the global mass spectrometry imaging market includes profiles of some of the major companies such as Thermo Fisher Scientific Inc., Danaher Corporation, Waters Corporation, Bruker Corporation, Shimadzu Corporation, JEOL Ltd. and Analytik Jena AG.



Below are the active patents related to Mass Spectrometry Imaging Market.


Patent Number: EP2455759A1

Mass spectrometry imaging with substance identification

Abstract

The invention relates to the mass spectrometry imaging of histologic thin tissue sections, where a mass spectrum is acquired for every image point. The invention provides a method for the identification and localization of proteins or other biomolecules of a histologic thin tissue section, comprising the following steps: a) the biomolecules of two similar thin tissue sections are enzymatically digested, substantially preserving the biomolecule positions in the tissue; b) a mass spectrometric image of the digest products in the first thin tissue section is acquired; c) the digest products of the second tissue section are extracted and separated with the aid of a separation method, and then introduced into a tandem mass spectrometer, which acquires mass spectra and daughter ion spectra of all the digest products present; d) a list of all identifiable biomolecules of the tissue is created by comparison of the mass spectra and daughter ion spectra of the digest products with spectra derived from biomolecule structure databases or correspondent spectral libraries; and e) the biomolecules in the list are assigned, on the basis of the masses of their digest products, to the digest products of the same mass in the mass spectra of the mass spectrometric image of the thin tissue section, after intelligent filtering, where necessary. With the aid of correlations of the mass-selective images, digest products can be identified as being wrongly assigned. The summation of well-correlating mass-selective images of the digest products of the biomolecules produces biomolecule-selective images, i.e. images of the distribution of the individual biomolecules in the thin tissue section.

Application File Date: 2011-11-09

Application Granted Date: 2015-01-07

Current Assignee: Bruker Daltonik GmbH

Patent Number: US9299553B2

Atmospheric pressure ion source for mass spectrometry

Abstract

A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control.

Application File Date: 2014-03-26

Application Granted Date: 2016-03-29

Current Assignee: CHEM-SPACE ASSOCIATES Inc, PerkinElmer Health Sciences Inc

Patent Number: US20090250608A1

Ion Sources For Improved Ionization

Abstract

Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry.

Application File Date: 2009-04-03

Application Granted Date: 2011-10-18

Current Assignee: Agilent Technologies Inc

Key Market Segments:

By Type

  
MALDI
  
ESI
  
Others

By Application

  
Proteomics
  
Clinical
  
Metabolomics


Key Market Players included in the report:


  
Advion (US)
  
Agilent Technologies (US)
  
AMETEK Process Instruments (US)
  
Analytik Jena AG
  
Bruker Corporation
  
Danaher Corporation (Sciex)
  
DANI Instruments (Italy)
  
Endress+Hauser Group
  
Extrel CMS (US)
  
FLIR Systems (US).
  
Hiden Analytical (UK)
  
JEOL (Japan)
  
Kore Technology (UK)
  
LECO (US)
  
MassTech Inc. (US)
  
MKS Instruments (US)
  
PerkinElmer (US)
  
Rigaku (Japan)
  
SCIEX (US)
  
Shimadzu Corporation (Japan)
  
Thermo Fisher Scientific (US)
  
Waters Corporation (US)


Below are the key development related to Mass Spectrometry Imaging Market in 2020 and 2021.


June 2021: Trace Matters Successfully Demonstrates Proof-of-Principle for SPion™ Technology in Collaboration With Thermo Fisher Scientific. Trace Matters Scientific in collaboration with Thermo Fisher Scientific successfully demonstrated the proof-of-principle for SPionTM Technology for mass spectrometry. For the experiments conducted at Thermo Fisher’s San Jose office, SPionTM Technology was coupled to Thermo Fisher’s TSQ AltisTM Triple Quadrupole Mass Spectrometer, one of the world’s most sensitive mass spectrometers in the market. The experimental results acquired using standard calibration solutions confirmed that SPion™ delivers excellent analytical performance, and can efficiently transfer ions in both positive and negative mode in a wide mass range. As an award winner from NASA’s Science Mission Directorate, SPion™ is a revolutionary mass spectrometry technology that defines a new architecture for the front end of a mass spectrometer. Empowered by the world’s first and only flexible ion guide for lossless ion transfer, SPion™ seamlessly bridges the gap between sample and mass spectrometer. By overcoming a major instrumentation bottleneck, SPion™ offers endless opportunities for scientists and researchers to develop and introduce new generations of advanced front end peripheral technologies for mass spectrometry that were not possible to develop before, including a variety of probes, multimodal imaging stations, and sample preparation product suites for research and industrial markets, such as environmental, clean energy, water analysis, pharmaceutical, and healthcare. Source

June 2021: JEOL Ltd.(TOKYO:6951) (President & COO Izumi Oi) and SCiLS, a division of Bruker Daltonics, announced that they have concluded a non-exclusive, worldwide distribution agreement for SCiLS Lab MVS software. The SCiLS Lab has been the software of choice for researchers wanting to gain new insights from mass spectrometry imaging. Used in science and industry, the software sets new standards in analysis and visualization, simplifying everyday work and advancing the research. The SCiLS Lab MVS (Multi-Vender Support) can be used for the analysis of mass spectrometry imaging datasets based on the open imzML data format. SCiLS Lab MVS offers all features of SCiLS Lab and it allows the statistical analysis and visualization of mass spectrometry imaging data of virtually unlimited size in two and three spatial dimensions. Source

March 2021: GlycoPath Inc. Secures Seed Investment to Further Develop, Validate and Commercialize GlycoTyper™ Mass Spectrometry-Based Assays for Liver Fibrosis, Cirrhosis and Liver Cancer (HCC). CHARLESTON, S.C.  GlycoPath Inc., the developer of advanced bioanalytical assays based on its proprietary GlycoTyperTM immunoaffinity technology, announced the closing of its seed investment round with Bruker Corporation (Nasdaq: BRKR) as a new minority investor. Financial details were not disclosed. The proprietary GlycoTyperTM glycan profiling technology captures diagnostic glycoproteins from blood using multiplexed antibody slide arrays, followed by direct analysis of the glycans present on each glycoprotein by MALDI-TOF mass spectrometry. Presently, the GlycoTyperTM technology is for research use only. The initial pathology target for GlycoTyperTM, hepatic fibrosis, is currently one of the fastest growing diseases in the US by annual case numbers, and may affect over 100 million people in the US and 1.5 billion individuals worldwide. In addition to providing initial patient screening and risk stratification for liver fibrosis, the planned LDT (laboratory-developed test) assay will be positioned for routine surveillance of at-risk populations. The test is not affected by co-morbidities such as obesity, which are problematic for current fibrosis diagnostic testing protocols. Source

October 2020: Product News: Hamamatsu Photonics expands its lineup of ionization-assisting substrates. Hamamatsu Photonics have added four new products to its “DIUTHAME” (Desorption Ionization Using Through Hole Alumina Membrane) series ionization-assisting substrates, that drastically cut the pretreatment time needed to ionize samples by laser in mass spectrometry. These new products include a miniature type, ideal for mass spectrometry imaging of small samples and a glass-slide size type for mass spectrum measurement that can be directly set into spectrometer holders. Source

September 2020: Ionpath Closes $18M Series B Round. Source