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Abstract, Snapshot, Market Analysis & Market Definition: Acne Drugs Market The global acne drugs market size was valued at USD 4.1 billion in 2017 and is anticipated to register a CAGR of 4.2% during the forecast period. The market is projected to exhibit moderate growth over the forecast period, which can be attributed to factors such as emergence of biologics, unhealthy lifestyle, and rising disease incidence. Acne is a common dermatological condition, affecting more than 9.4 million worldwide. Abnormal hormone production is a key causative factor. Rise in androgen (estrogen, in women) levels during puberty triggers the onset of this condition by enlarging oil glands under the skin. This leads to excessive sebum production, which breaks down cell walls in pores leading to bacterial invasion. Although some studies suggest that the risk of developing acne may be increased due to genetic causes, certain factors such as emotional stress, menstruation, hot and humid climate, and greasy cosmetics can trigger the condition. The skin condition was ranked the eighth most prevalent disease in 2015. However, despite being one of the most common dermatological diseases in the world, innovation in this market has been rather limited over the past decade. Most of the novel products are reformulated drugs with improvised vehicles or combinatorial therapies. The treatment algorithm is witnessing a paradigm shift from small molecules towards peptides and biologics. Combination therapies have also been gaining popularity over the last few years. Most industry-sponsored products are in Phase II trials. Failure of pivotal clinical trials for key candidates including olumacostat glasaretil and SNA-001 remains an impediment to growth. Off-label use of anti-acne drugs such as Diane-35 as birth-control measures may lead to serious consequences such as breast cancer and venous thromboembolism (VTE). Additionally, adverse effects associated with these drugs, such as nausea, high blood pressure, and birth defects (as in case of isotretinoin), continue to restrain the market. Nevertheless, impending approval of a range of novel products offers a promising future for the global market. Market Segmentation, Outlook & Viewpoint: Acne Drugs Market This report forecasts revenue growth at global, regional, and country levels and provides an analysis on latest industry trends in each of the sub-segments from 2017 to 2025. For the purpose of this study, Grand View Research has segmented the global acne drugs market report based on type, therapeutic class, mode of administration, and country: Type Outlook (Revenue, USD Million, 2017 - 2025) Comedonal Inflammatory Cystic Postsurgical/wound Therapeutic Class Outlook (Revenue, USD Million, 2017 - 2025) Retinoid Antibiotic Hormonal Agent Combination Others Mode of Administration Outlook (Revenue, USD Million, 2017 - 2025) Topical Oral Injectable Key Players, Recent Developments & Regional Insights: Acne Drugs Market Inflammatory acne is the largest segment by type. The condition occurs when pores are deeply clogged, resulting in swelling and redness. Bacterial infection may further aggravate this condition. Inflammatory acne captured more than 50.0% of the market in 2017, closely followed by comedonal type. Cystic acne is the most serious form and affects relatively fewer people.OTC drugs are not usually strong enough for treating cystic acne. Post-surgical/wound acne occurs as a consequence of bacterial infection at the site of wound/surgery. Therapeutic Class Insights Retinoids and antibiotics remain the mainstay of the acne drugs market. Retinoids dominated the therapeutic classes in 2017, closely followed by antibiotics. It is expected that retinoids will prevail as market leaders through 2025,driven by their first-line action and impending approval of pipeline products. Antibiotics are often administered in combination with benzoyl peroxide to prevent antibiotic resistance. The treatment paragon is likely to shift from monotherapy to combination therapy. Combination therapeutics are gaining traction on account of higher efficacy, improved results, reduced resistance, and convenient usage. Hormonal agents are generally used in severe cases. Oral contraception is a well-known form of hormonal treatment for acne. This method is often preferred by women who, in addition to suffering from acne, have interest in contraceptive benefits. However, hormonal therapy is not stand-alone and is synergistically combined with benzoyl peroxide, azelaic acid, antibiotics, and retinoids. Other agents used for treatment include sulfur, hydroxy acids, BPO, salicylic acid, and azelaic acid. Mode of Administration Insights Topical therapies dominated the market in 2017 by route of administration. Retinoids, antibiotics, BPO, salicylic acid, and azelaic acid are administered topically for mild-to-moderate acne as well as maintenance therapy. Oral medications are recommended as systemic therapies after topical treatments fail to evoke response. Treatment of severely inflamed or cystic acne may require cortisone injections.Emergence of biologics is likely to fuel growth of injectables. Gevokizumab (Novartis/XOMA), RA-18C3 (XBiotech), and CJM112 (Novartis) are investigational monoclonal antibodies for acne treatment. All three candidates involve subcutaneous mode of injection. Country Insights U.S. held the largest revenue share among the seven major markets for acne treatment in 2017. It is expected that this regional market will witness steady growth over the coming years, retaining its lead through 2025. Growth will be collectively driven by lifestyle changes, rising disease incidence, and easy availability of products. Disease prevalence is relatively lower in the EU5 than in U.S. This could be due to several reasons such as climatic conditions, less active or dormant genes, and dietary habits. It is anticipated that Japan will observe the fastest growth among the seven major markets due to increasing disease awareness, high unmet clinical needs of patients, and rising disposable income. Acne Drugs Market Share Insights Key players operating in this market include Allergan, Bayer, Galderma, Stiefel, and Valeant. Valeant dominated the competitive landscape in 2017, by virtue of its wide array of anti-acne products. Valeant is likely to retain its lead in 2025 driven by strong sales of Retin-A Micro, Onexton, and Solodyn, as well as launch of pipeline products. Foamix, Cassiopea, and Novan are anticipated to enter this arena, following the launch of their anti-acne products during the forecast period. Sol-Gel Technologies, AndroScience Corporation, and Mimetica are some of the promising companies in this therapeutic space. Failure in late-stage clinical trials for key candidates stands as an impediment to this market. Olumacostat glasaretil (Dermira), SNA-001 (Sienna), TSN2898 (Thesan), XEN801 (Xenon), and JNJ-10229570 AAA (Valeant) have faced discontinuation in the recent past. Key Insights Covered: Global Acne Drugs Market 1. Market size (sales, revenue and growth rate) of Acne Drugs industry. 2. Global major manufacturers' operating situation (sales, revenue, growth rate and gross margin) of Acne Drugs industry. 3. SWOT analysis, New Project Investment Feasibility Analysis, Upstream raw materials and manufacturing equipment & Industry chain analysis of Acne Drugs industry. 4. Market size (sales, revenue) forecast by regions and countries from 2019 to 2025 of Acne Drugs industry. Research Methodology: Acne Drugs Market
- Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analyzed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more please Request a Sample Report.
- Demand Side Primary Contributors: OEMs, Industrial Professionals, Researches, Suppliers and Distributors, Group Purchasing Organizations, Associations, Insurers, Universities, Technological Writers, Scientists, Promoters, Investors among others.
- Supply Side Primary Contributors: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, Regulatory Affairs Managers among others.
Table of Contents Chapter 1 Methodology and Scope 1.1 Research Methodology 1.2 Research Scope and Assumptions 1.3 List to Data Sources 1.4 List of AbbreviationsChapter 2 Executive SummaryChapter 3 Disease Primer and Epidemiology 3.1 Disease Primer 3.1.1 Forms 3.1.2 Causative Factors and Triggers 3.1.3 Degree of Severity 3.2 Epidemiology 3.3 Current Prevalence and Incidence for Seven Major Markets (U.S., Japan, EU5) 3.4 Forecast Prevalence and Incidence for Seven Major Markets (U.S., Japan, EU5)Chapter 4 Global Acne Drugs Market Overview 4.1 Introduction and | read more...