Global Oligonucleotide Synthesis Market Size, Sector / Industry Report & Analysis, 2025 (Includes Business Impact of COVID-19)

                                          
Abstract, Snapshot, Market Analysis & Market Definition: Global Oligonucleotide Synthesis Market


The global oligonucleotide synthesis market size was estimated at USD 1.5 billion in 2017. Declining cost of sequencing has resulted in rising demand for custom-made nucleotides for desired sequence across research, genetic testing, drug development, and forensic applications. This, in turn, has fostered demand for oligonucleotide synthesis across various life science industries.
Oligonucleotide synthesis is an integral part of several ongoing genetic research studies. Rising investments in genetic research are anticipated to boost demand for custom synthesis of different classes of oligos including decoys, aptamers, immunostimulatory, antisense, siRNA, and miRNA.
 
Several major and emerging oligonucleotides manufacturers are expanding their businesses through collaboration with pharmaceutical manufacturers. For instance, in June 2017, CordenPharma International signed a strategic collaboration with GE Healthcare Dharmacon Inc. for development of an end-to-end oligonucleotide-based drug discovery solution.
A substantial number of oligos are under late phase clinical trials targeting various conditions such as cancer, cardiovascular diseases, muscle dystrophies, and ocular disorders. This anticipated regulatory approval for multiple oligonucleotide-based therapies is expected to propel the market.
Marketing approaches implemented in this market include direct selling and selling via distributors in specific countries. The market is expected to benefit from constant growth of genomics and gene editing markets, as advancement in genetic tools would simplify the synthesis of oligonucleotides.

Market Segmentation, Outlook & Viewpoint: Global Oligonucleotide Synthesis Market


Product Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

Oligonucleotides

Oligonucleotides, By Product Type

Column-based Oligos

Array-based Oligos


Oligonucleotides, By Nucleic Acid Type

DNA

RNA



Equipment

Reagents

Services

Oligo Synthesis

25 nmol

50 nmol

200 nmol

1000 nmol

10,000 nmol


Purification

Modification



Application Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

PCR Primers

PCR Assays and Panels

Sequencing

DNA Microarrays

Fluorescence In Situ Hybridization (FISH)

Antisense Oligonucleotides

Other Applications


End-use Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

Academic Research Institutes

Diagnostic Laboratories

Pharmaceutical - Biotechnology Companies


Key Players, Recent Developments & Regional Insights: Global Oligonucleotide Synthesis Market


PCR primers are widely used in drug development for target screening and identification. Presence of a robust pipeline of oligonucleotides-based therapeutics, including antisense therapeutics, DNA vaccines, and anti-viral agents, in various phases of clinical development has allowed PCR primers to enjoy the largest revenue share in the oligonucleotide synthesis market.
Increase in focus on targeted gene therapies has revolutionized treatment of incurable conditions caused by genetic mutations. Increase in demand for sequencing applications by clinical, diagnostic, academic, and drug development is witnessed by manufactures.
End-use Insights
Pharmaceutical industries and biotechnology companies are focused on seeking alternative approaches for disease treatment. As a result, these companies are making significant use of oligonucleotides, as it offers an effective mode of action for treatment of various indications at comparatively lower development cost.
 
Furthermore, oligonucleotides play a vital role in overcoming challenges pertaining to efficient route of drug administration. This, in turn, is projected to increase manufacturing of oligonucleotide therapeutics, thereby enhancing the share of pharmaceutical and biotechnology companies in the global market.
Government and private entities are investing in development of academic and research infrastructure in emerging economies. This factor is expected to positively boost oligonucleotide adoption in academic research institutes. Surge in genomic research projects conducted by academic research institutes has enabled this segment to account for the dominant share in the market. Moreover, collaboration among major players and universities for development of novel approaches to cure chronic conditions through genetic medicine is expected to contribute to the growth of this segment.

Regional Insights
Presence of innovators and key players in U.S. has resulted in higher penetration of products in the market. This has allowed North America to account for a significant revenue share in 2017. Furthermore, the strong foothold of North America in genomics, proteomics, oncology, diagnostic screening, and drug discovery has significantly contributed to maintaining its large share.
Asian countries are recognized as the fastest adopters of sequencing, array technology, and PCR products due to rapid progress in genomics studies and the healthcare sector. Japan and China are considered as the most attractive markets with respect to expansion and growth opportunities present in these countries. In addition, changing economic scenario, along with high investments in healthcare, life science-related research programs, and genetics, has encouraged global players to enter the Asia Pacific market, thus aiding its growth.
Oligonucleotide Synthesis Market Share Insights
Some key companies operating in the market are Thermo Fisher Scientific, Inc.; Merck - Co., Inc.; GE Healthcare Dharmacon Inc.; Agilent Technologies; Bio-synthesis; Kaneka Eurogentec S.A.; Integrated DNA Technologies, Inc.; BioAutomation; and LGC Biosearch Technologies. The market is highly competitive due to rigorous strategies adopted by these players in order to capture a greater market share.
Various strategies adopted by these competitors include acquisition of players in emerging markets, distribution partnerships, and collaboration for development of novel technologies and products. For instance, in February 2017, Integrated DNA Technologies acquired GeneWorks Pty Ltd., an oligonucleotide manufacturer in Australia through its Singapore-based subsidiary.

Key Insights Covered: Global Oligonucleotide Synthesis Market
1.  North America, Europe, Asia Pacific, Middle East & Africa, Latin America market size (sales, revenue and growth rate) of Oligonucleotide Synthesis industry.
2. Global major manufacturers' operating situation (sales, revenue, growth rate and gross margin) of Oligonucleotide Synthesis industry.
3. Global major countries (United States, Canada, Germany, France, UK, Italy, Russia, Spain, China, Japan, Korea, India, Australia, New Zealand, Southeast Asia, Middle East, Africa, Mexico, Brazil, C. America, Chile, Peru, Colombia) market size (sales, revenue and growth rate) of Oligonucleotide Synthesis industry.
4. SWOT analysis, New Project Investment Feasibility Analysis, Upstream raw materials and manufacturing equipment & Industry chain analysis of Oligonucleotide Synthesis industry.
5. Global market size (sales, revenue) forecast by regions and countries from 2019 to 2024 of Oligonucleotide Synthesis industry.

Research Methodology: Global Oligonucleotide Synthesis Market

Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analyzed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more please Request a Sample Report.
Demand Side Primary Contributors: OEMs, Industrial Professionals, Researches, Suppliers and Distributors, Group Purchasing Organizations, Associations, Insurers, Universities, Technological Writers, Scientists, Promoters, Investors among others.
Supply Side Primary Contributors: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, Regulatory Affairs Managers among other