Global Antibiotic Resistance Market Size, Sector / Industry Report & Analysis 2020, & Forecast 2021-2026 (Includes Business Impact of COVID-19)

                                          
Abstract, Snapshot, Market Analysis & Market Definition: Global Antibiotic Resistance Market


The global Antibiotic Resistance market size is projected to reach US$ 12.75 billion by 2026, from US$ 9.2 billion in 2020, at a CAGR of 5.6% during 2021-2026. High burden of antibiotic-resistant infections and emergence of multi-drug resistant pathogens have been augmenting the market.

Pharmaceutical companies, such as GlaxoSmithKline, Johnson & Johnson, Novartis, and Sanofi, are at the forefront of the global pharmaceutical industry but are less actively involved in clinical development of antibiotics. Majority of large pharmaceutical companies find the market lucrative enough due to relatively slower growth in revenues for marketed drugs and lower return on investments. For instance, Novartis recently cancelled all plans to continue with R&D for its antibacterial drugs.

On the other hand, there are several biotech companies including Melinta Therapeutics, Achaogen, and Nabriva Therapeutics that have undertaken the challenge of developing therapies for antibiotic resistance. Involvement of international organizations serves as a catalyst in developed markets. Funding bodies such as BARDA are supporting biotech companies with financial support to complete early stage development of their novel therapies for antibiotic resistant infections.

Manufacturers seek the Qualified Infectious Disease Product (QIDP) designation, which expedites the clinical review process and extends exclusivity period for new generation antibiotics of strong therapeutic value. The QIDP designation was introduced under the Generating Antibiotic Incentives Now (GAIN) Act, passed in 2012 as an extension to the U.S. Food and Drug Administration Safety and Innovation Act. The legislation aims to promote the development of new therapies for growing burden and severity of antibiotic-resistant infections.

Market Segmentation, Outlook & Viewpoint: Global Antibiotic Resistance Market

Disease Market Segmentation & Outlook (Revenue, USD Billion, 2014 - 2025)

  
Complicated Urinary Tract Infection (cUTI)
  
Complicated Intra-Abdominal Infections (cIAI)
  
Blood Stream Infections (BSI)
  
Clostridium difficile infections (CDI)
  
Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
  
Hospital Acquired Bacterial Pneumonia/Ventilator (HABP/VABP)
  
Community Acquired Bacterial Pneumonia (CABP)
  
Pathogen Market Segmentation & Outlook (Revenue, USD Billion, 2014 - 2025)
  
Acinetobacter baumannii (Carbapenem-Resistant and ESBL-producing)
  
Pseudomonas aeruginosa (Carbapenem-Resistant)
  
Staphylococcus Aureus (Methicillin-Resistant)
  
E. coli/K. pneumoniae (Carbapenem-Resistant)
  
Streptococcus pneumoniae (Penicillin-Non-Susceptible)
  
Clostridium difficile (Cephalosporin-Resistant, Tetracycline-Resistant)
  
Enterococcus faecium (Vancomycin-Resistant)
  
Haemophilus Influenzae (Ampicillin-Resistant)

Drug Class Market Segmentation & Outlook (Revenue, USD Billion, 2014 - 2025)

  
Oxazolidinones
  
Lipoglycopeptides
  
Tetracyclines
  
Cephalosporins
  
Combination therapies
  
Others

Key Players, Recent Developments & Regional Insights: Global Antibiotic Resistance Market

Based on disease type, the market has been categorized into cUTI, cIAI, BSI, CDI, ABSSSI, HABP/VABP, and CABP. cUTI represented the largest segment in the market in 2017 owing to high overall treatment cost and limited treatment alternatives for Gram-negative pathogens, which account for majority of infection cases. Lack of low-cost treatment options for Gram-negative infections limits access to recently approved branded therapies such as Allergans Avycaz, Mercks Zerbaxa, and Melinta Therapeutics Vabomere.

Antibiotic-resistant Gram-positive bacteria account for a larger number of infections by volume. However, due to availability of multiple treatment options including branded and generics drugs, the overall cost of therapy remains lower when compared with Gram-negative infections. Among gram-positive infections, MRSA accounted for the highest market share, being the primary causative pathogen for growing ABSSSI burden across the globe. The ABSSSI segment is projected to command a sizeable share in the antibiotic resistance market throughout the forecast period.

Pathogen Insights

Infections due to K. pneumoniae pathogens that are carbapenem-resistant and ESBL-producing held the largest share in 2017. These infections pose treatment challenges for physicians due to high resistance to current treatment alternatives. These infections although fewer in terms of number of cases in comparison to Gram positive pathogens, they impose a high cost burden as physicians are increasingly shifting towards novel antibiotics such as Allergans Avycaz and Melinta Therapeutics Vabomere. CDI, on the other hand, is anticipated to register the highest CAGR during the forecast period.

Drug Class Insights

Based on drug class, the market has been segmented into oxazolidinones, lipoglycopeptides, tetracyclines, cephalosporins, combination therapies, and others, which includes miscellaneous drug classes. Lipoglycopeptides are likely to command 17.0% of the overall market revenue by 2025.

The combination therapies segment, which comprises fixed dose combinations of beta lactams and beta lactamase inhibitors, is poised to experience the highest growth during the forecast period. High use of these therapies for gram negative infections that have limited treatment options is contributing to the growth of the segment.

Regional Insights

North America was the largest region in terms of revenue in 2017. Numerous drug launches in the market and high treatment cost are supplementing the growth of the regional market. The U.S. will be a key revenue contributor in the region during the forecast period as guidelines, such as those defined by IDSA for the treatment of CDI, are promoting the use of novel therapies.

Europe was the second largest regional market in the global arena in 2017, supported largely by growing number of antibiotic-resistant infections. Among the OECD countries, Greece, Italy, and Portugal were ranked as the top 3 consumers of antibiotics in the world, contributing to increased antibiotic resistance in the region.

Antibiotic resistance Market Share Insights

Some of the key players in the market are Pfizer, Merck, Allergan, and Melinta Therapeutics. This market has fewer pharmaceutical companies entering the space, while the number of biotech companies such as Achaogen and Nabriva Therapeutics is higher.

Large pharmaceutical companies are acquiring smaller entrants with novel antibiotics. The trend is expected to shape the future of the market. For instance, Pfizer acquired Astra Zenecas marketed drugs, Zavicefta and Zinforo, and late stage antibiotics, ATM-AVI,resulting in an expanded portfolio of antibiotics. In addition, companies in the market target for higher market share through indication extension and geographic expansion strategies.

Key Insights Covered: Global Antibiotic Resistance Market

1. North America, Europe, Asia Pacific, Middle East & Africa, Latin America market size (sales, revenue and growth rate) of Antibiotic Resistance industry.
2. Global major manufacturers operating situation (sales, revenue, growth rate and gross margin) of Antibiotic Resistance industry.
3. Global major countries (United States, Canada, Germany, France, UK, Italy, Russia, Spain, China, Japan, Korea, India, Australia, New Zealand, Southeast Asia, Middle East, Africa, Mexico, Brazil, C. America, Chile, Peru, Colombia) market size (sales, revenue and growth rate) of Antibiotic Resistance industry.
4. SWOT analysis, New Project Investment Feasibility Analysis, Upstream raw materials and manufacturing equipment & Industry chain analysis of Antibiotic Resistance industry.
5. Global market size (sales, revenue) forecast by regions and countries from 2019 to 2024 of Antibiotic Resistance industry.

Research Methodology: Global Antibiotic Resistance Market

  
Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analyzed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more please Request a Sample Report.
  
Demand Side Primary Contributors: OEMs, Industrial Professionals, Researches, Suppliers and Distributors, Group Purchasing Organizations, Associations, Insurers, Universities, Technological Writers, Scientists, Promoters, Investors among others.
  
Supply Side Primary Contributors: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, Regulatory Affairs Managers among other