Global High-performance Liquid Chromatography (HPLC) Market By Product Type (Instruments, Consumables, Accessories), By End User (Pharmaceutical & Biotechnology, Cros, Academic And Research Institutes), By Region and Key Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends and Forecast 2021-2030 (Includes Business Impact of COVID-19)

                                          
Report updated on 11th September, 2021: Global High-performance Liquid Chromatography (HPLC) Market By Product Type (Instruments, Consumables, Accessories), By End User (Pharmaceutical & Biotechnology, Cros, Academic And Research Institutes), By Region and Key Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends and Forecast 2021-2030 (Includes Business Impact of COVID-19)
Trusted Business Insights has published a comprehensive market research report on, Global High-performance Liquid Chromatography (HPLC) Market by Product Type (Instruments, Consumables, Accessories), By End User (Pharmaceutical & Biotechnology, CROs, Academic and Research Institutes, Other End Users ), and by Region -Global Forecast to 2030, which offers a holistic view of the global High-performance Liquid Chromatography (HPLC) market through systematic segmentation that covers every aspect of the target market.

The global high-performance liquid chromatography (HPLC) market is projected to be US$ 4,108.2 Mn in 2020 to reach US$ 6,529.2 Mn by 2030 at a CAGR of 4.7%.

HPLC is the chromatography technique. It is known as High-Performance Liquid Chromatography technique. This technique of analytical chemistry is used to separate, identify and quantify every single component of the mixture. Liquid chromatography is a technique in which the mobile phase used is liquid. HPLC is dependent on the pump to pass solvent which contains a mixture through a column which is filled with a solid adsorbent material. Every component in the sample interacts differently with adsorbent, because of which different component flows at different work rates, and it leads to separation of the component as they flow through the column. Here detector generates a signal proportional amount of sample evolving from the column. Different types of detectors are used such as UV-Vis or LCMS etc. There are two types of HPLC techniques one is Normal Phase HPLC, and the other is Reverse Phase HPLC. Out of these two techniques, reversed phase HPLC is mostly used. Two types of columns are used in HPLC, one is higher pressure resistance, and the other is low-pressure resistance. Most columns are made up of steel are used for high-pressure resistance and glass or Peek columns are used for low-pressure resistance, especially when inert surfaces are required for chemical or biological applications.

Higher accuracy and sensitivity of HPLC, increasing acceptance of the LC-MS technique and rising significance of high-performance liquid chromatography tests in drug approvals are expected to bolster the growth of the HPLC market in future. Furthermore, increasing consumption of processed and packaged food has increased the usage of HPLC, which in turn is expected to boost the target market.


Global High-performance Liquid Chromatography (HPLC) Market Revenue (US$ Mn), 2021 to 2030


However, the high cost of HPLC system is a significant factor expected to hamper the growth of high-performance liquid chromatography (HPLC) market. Also, the high cost associated with servicing results in operational expense is another crucial factor expected to limit the growth of the target market. Nonetheless, the combination of liquid chromatography and the ultra-high resolution accurate mass performance delivers an orthogonal separation that can improve the depth of coverage, particularly for isomeric mass lipid species that may be present which is expected to enhance the market growth in future.

Global high-performance liquid chromatography (HPLC) market is segmented on the basis of Product Type, End User and region. On the basis of product type, the market is segmented into

instruments, consumables, accessories. The consumables segment further segmented into columns, filters, vials, tubes. Consumables segment accounts for the majority share and is expected to register the highest growth over the forecast period. In consumables segment columns, the segment accounts for the majority share. On the basis of end user, the market is segmented into pharmaceutical & biotechnology, CROs, academic and research institutes, other end users. The pharmaceutical & biotechnology segment accounts for a majority share in the global high-performance liquid chromatography (HPLC) market. CROs segment is expected to register the highest growth over the forecast period.


Global High-performance Liquid Chromatography (HPLC) Market by Formulation, 2018


On the basis of region, the market is segmented into North America, Europe, APAC, South America and Middle East Africa. North America accounts for the majority share in the global high-performance liquid chromatography (HPLC) market, followed by Europe. APAC is expected to register the highest growth rate after over forecast period, owing to growing usage of chromatography in the purification technique of monoclonal antibodies. Regions such as South America and MEA are expected to register stable growth over the forecast period.

The research report on the global High-performance Liquid Chromatography (HPLC) market includes profiles of some of the major companies such as Thermo Fisher Scientific Inc. Agilent Technologies, Inc., Shimadzu Corporation, Waters Corporation, Bio-Rad Laboratories, Inc., PerkinElmer, Inc., General Electric Company, Danaher Corporation.



Below are the active patents related to High-performance Liquid Chromatography (HPLC) Market.


Patent Number: CN102128886B

High performance liquid chromatography method for measuring stabilizer BHT content of tetrahydrofuran

Abstract

The invention discloses a high performance liquid chromatography method for measuring stabilizer 2,6-ditertiary butyl-4-methyl phenol (BHT ) content of tetrahydrofuran, which comprises the following steps of: 1) setting the conditions of high performance liquid chromatography, namely a C18 inverse phase chromatographic column has a length of 5 microns and an inside diameter of 150*4.6 millimeters (I.D.), the ratio of mobile phone to methanol to acetonitrile to water is 50-70: 10-40: 10-30 (v/v), the flow rate is 1.0ml/min, the column temperature is 40 DEG C, the detection wavelength is 277 nanometers, the sampling volume is 5.0mul and the retention time is 27.0 minutes; 2) preparing stabilizer BHT standard solution; 3) making a standard curve; and 4) measuring sample content, wherein the measured lowest detection limit of the stabilizer BHT is 0.0002mg/ml. By the method, the stabilizer BHT content of the tetrahydrofuran can be accurately measured, and reliable detection data are provided for ensuring the stability of the BHT content of a tetrahydrofuran product and the quality control of the product.

Application filed by Date:2010-12-09

Application granted Date: 2013-06-19

Current Assignee: Sinopharm Chemical Reagent Co Ltd

Patent Number: US9114335B1

Reusable liquid chromatographic column

Abstract

A reusable liquid chromatographic column consists of three parts, a column body with an integral outlet port molded on one end, a sealing insert with an inlet port, and a perforated cap providing downward force to compress the sealing insert into the column body. A wedge-like seal is employed to seal the connection between the sealing insert and the column body. Two filters on both ends of the column body are used to prevent escape of packing materials from the column chamber under pressure. Hand tightening is adequate to seal the connection by screwing the perforated cap onto the column body. The column is reusable due to its simple disassembling and reassembling processes. It is also disposable due to its inexpensive fabricating materials and manufacturing process.

Application filed by Date: 2010-02-12

Application granted Date: 2015-08-25

Current Assignee: Luknova Inc

Patent Number: US20170097327A1

Chromatography columns, systems and methods

Abstract

The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

Application filed by Date: 2016-12-14

Application granted Date: 2018-08-14

Current Assignee: Cytiva Bioprocess R&D AB

Key Market Segments

By Type

  
Instruments
  
Consumables
  
Accessories

By Application

  
Pharmaceutical & Biotechnology
  
CROs
  
Academic and Research Institutes


Key Market Players included in the report:


  
Agilent Technologies
  
Bio-Rad Laboratories Inc.
  
Danaher Corporation
  
General Electric Company
  
Gilson, Inc.
  
Hamilton Company (US)
  
Higgins Analytical Inc.
  
Hitachi (Japan)
  
JASCO (US)
  
Merck Millipore (Germany)
  
Orochem (US)
  
PerkinElmer, Inc.
  
Phenomenex Inc.
  
Restek (US)
  
Shimadzu Corporation
  
Showa Denko (Japan)
  
SIELC (US)
  
Thermo Fisher Scientific Inc
  
Tosoh Bioscience LLC (Japan).
  
Trajan Scientific (Australia)
  
Waters Corporation
  
YMC Co. Ltd. (Japan)


Below are the key development related to High-performance Liquid Chromatography (HPLC) Market in 2020 and 2021.


June 2021: Trivitron Healthcare launches HPLC-based diagnostic solutions. The HPLC-based HbA1c analysers will be used for monitoring diabetes, thalassemia and haemoglobin variants. Trivitron Healthcare has launched two new innovation-driven products for HbA1c and Hb variant detection. The new product includes NANO H5 & NANO H110 which are high-performance liquid chromatography analysers for HbA1c detection in less than three minutes. These HPLC-based HbA1c analysers will be used for monitoring diabetes, thalassemia and haemoglobin variants. NANO H5, is a compact, automated HPLC analyser that uses ion exchange liquid chromatography for the quantitative determination of the glycated haemoglobin (HbA1c) in human whole blood with a processing time of 130 seconds that will expedite the laboratory TAT. The fully automated analyser which promises to process five samples at a time will take Trivitron Healthcare to reach the pinnacle of precision within a designated time frame in the global diagnostic market. Source

February 2021: Easy-to-Use Reversed-Phase Capillary Columns and Emitters Improve High-Resolution LC-MS Analysis. The Thermo Scientific MAbPac Reversed-Phase Capillary HPLC Columns and Emitters achieve sensitive, reproducible and robust high throughput analysis with minimal sample volume. Proteomics, clinical peptides and biopharmaceutical research laboratories performing high throughput, high-performance liquid chromatography (HPLC), or liquid chromatography-mass spectrometry (LC-MS) analysis can now benefit from novel capillary chromatography columns and nano- and capillary emitters, specifically designed for highly sensitive top-down, middle-down analysis. These columns and emitters enable laboratories to achieve high-resolution, low-flow separations for intact proteins, monoclonal antibodies (mAbs) and peptides. The Thermo Scientific MAbPac Reversed-Phase (RP) Capillary HPLC Column builds upon the separation power and reliability of the proven MAbPac RP chemistry in analytical flow. Together with the new Thermo Scientific EASY-Spray Nano and Capillary Emitters, the temperature-controlled MAbPac column enables maximum reliability and performance, while also providing excellent resolution, long column lifetime and low carry-over. The capillary format of the LC column improves sensitivity, achieving outstanding data results even with smaller sample volumes. The format makes the versatile column ideal for applications such as peptide mapping characterization and analysis of mAbs fragments, antibody drug conjugates (ADC) and PEGylated proteins. Source

November 2020: PerkinElmer Launches New HPLC, UHPLC and Next Generation Software Solution. LC 300™ platform and SimplicityChrom™ software offers improved workflows, intuitive user interface and 21 CFR Part 11 compliance.WALTHAM, PerkinElmer, Inc., introduced the LC 300™ platform and SimplicityChrom™ software, bringing together advanced high-performance liquid chromatography (HPLC) and ultra-high performance liquid chromatography (UHPLC) capabilities with intuitive instrument control and data analysis. The new solution accelerates throughput, streamlines testing and enables user-friendly operation to enhance productivity for labs in multiple industries working to meet quality and regulatory goals and requirements. Source

June 2020: Waters Introduces the New Arc High-Performance Liquid Chromatograph to Help Laboratories Meet Quality and Production Targets.Modern LC System Replicates Established Test Methods, Delivers Improved Performance; Updates to Lab Business Continuity Solution Also Announced Most pharmaceutical quality control test methods are HPLC-based. If there’s one thing the Waters Arc HPLC System does extraordinarily well, it’s measure the concentration of any active ingredient and any known impurity in a finished product and record the results of those tests in compliance with regulatory and quality standards. MILFORD, Waters Corporation (NYSE:WAT) introduced the Waters™ Arc™ HPLC System, a new high-performance liquid chromatograph (HPLC) for routine testing in the pharmaceutical, food, academic and materials markets. A key target application is quality control laboratories performing batch release tests on small molecule pharmaceuticals. Waters also announced the availability of Waters™ Empower™ BC LAC/E™ with SecureSync, its newly enhanced data back-up and recovery solution purpose-built for organizations with distributed laboratory environments. The Arc HPLC System is for laboratories looking for a rugged, reliable and modern HPLC system that can run established HPLC methods regardless of the brand of liquid chromatograph on which they were originally developed, while preserving the chromatographic retention time reproducibility of those methods. The system offers ultra-low analyte carryover, superb injection precision and backpressure tolerance to 9,500 psi at 5.0 ml/min. It is designed to meet all the requirements of a top-of-the-line HPLC system in a cost-competitive package that takes routine testing to the next level.Source