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Industry Insights, Market Size, CAGR, High-Level Analysis: Pulmonary Arterial Hypertension MarketThe global pulmonary arterial hypertension market size was valued at USD 6.3 billion in 2019. It is expected to register a CAGR of 5.6% over the forecast period. Rising prevalence of Pulmonary Arterial Hypertension (PAH), robust drug pipeline, changing lifestyle, and increasing geriatric population is expected to drive the market during the forecast period. Supportive government initiatives for the development of orphan drugs (drugs for rare diseases) are projected to support the market for pulmonary arterial hypertension. For instance, the Rare Disease Act 2002 and Orphan Drug Act (ODA) 1983 in U.S. offer incentives such as tax credits for the development of orphan drugs. The Orphan Drug Act enables tax credits up to 50.0% of total R&D cost, funding for R&D, protocol assistance, waiver in FDA fees, and clinical tax incentives. These incentives encouraged pharmaceutical companies to invest in the development of orphan drugs for treating PAH. The Patient-Focused Drug Development initiative highlights the power of and advocacy for patient care in U.S. This initiative helped understand disease severity, impact of disease on patients lives, and available treatment options for diseases such as pulmonary arterial hypertension. This initiative also helped create awareness about rare diseases in U.S., which helped people undergo diagnosis and avail treatment of rare diseases, including PAH. In September 2019, Acceleron Pharma, Inc. received FDA orphan drug designation for Sotatercept for the treatment of pulmonary arterial hypertension. Sotatercept was evaluated in two Phase 2 trials: the PULSAR trial and the SPECTRA exploratory trial. The company met its primary and key secondary endpoints in patients with pulmonary arterial hypertension in January 2020. Innovations such as these are anticipated to drive the overall market for PAH treatment over the forecast period. Changes in lifestyle such as excessive alcohol consumption, lack of physical activity, smoking, and consumption of fast food increase the risk of hypertension and high blood pressure. Increased blood pressure subsequently gives rise to various diseases such as stroke, heart attacks, and pulmonary arterial hypertension. Pulmonary arterial hypertension is perceived as a variable health risk and is often related with morbidity and mortality due to its alliance with cardiovascular diseases. Furthermore, PAH is hard to detect as the symptoms of pulmonary arterial hypertension are often mild or nonspecific. Drug Class Insights On the basis of drug class, the pulmonary arterial hypertension (PAH) market has been segmented into Soluble Guanylate Cyclase (SGC) stimulators, prostacyclin and prostacyclin analogs, phosphodiesterase 5 (PDE-5), and Endothelin Receptor Antagonists (ERA). ERA and prostacyclin and prostacyclin analogs for treating PAH accounted for a significant market share in 2019. Opsumit and Tracleer target ETB and ETA receptors, whereas Volibris/Letairis targets the ETA receptor. Prostacyclin and its analogs accounted for a significant share in 2019 owing to the significant increase in the sales of this drug for treating pulmonary arterial hypertension. The growing use of oral prostacyclin agents such as Orenitram and Uptravi for the treatment of PAH also contributed to the significant share of the segment.
Regional Insights of Pulmonary Arterial Hypertension MarketNorth America dominated the PAH market in 2019 owing to the developed healthcare infrastructure in U.S. that facilitates access to advanced therapeutics for treating pulmonary arterial hypertension. Moreover, growing awareness, high diagnosis rate, and supportive government initiatives resulted in an increased demand for PAH treatment. A well-planned reimbursement structure and high awareness resulted in excellent diagnosis rate of PAH. In addition, supportive legislations such as Rare Disease Act 2002 and the Orphan Drug Act (ODA) 1983 in U.S. has increased the adoption of novel medication for treating PAH. Europe followed North America with agencies such asEuropean Medicines Agency (EMA) and European Society of Cardiology which promote early diagnosis of PAH. Growing prevalence of risk factors and associated diseases such as HIV increases the risk of PAH. Moreover, rising geriatric population, lifestyle changes, and exposure to pollution is anticipated to contribute toward the increasing prevalence of PAH in Europe. Asia Pacific is anticipated to register the highest CAGR of 6.7% over the forecast period. Improving healthcare system, rapid economic development, and huge population base drive the need for treating PAH. Moreover, high disease burden of HIV and diabetes, which are responsible for the development of the PAH, would support the regional market growth over the forecast period.
Market Share Insights of Pulmonary Arterial Hypertension MarketKey players in the PAH market include Johnson & Johnson Services, Inc. (Actelion Pharmaceuticals, Ltd.); Novartis International AG; Gilead Sciences, Inc.; United Therapeutics Corporation; GlaxoSmithKline plc (GSK); Pfizer, Inc.; Dong-A ST Co., Ltd.; Merck Sharp & Dohme Corp; Bayer HealthCare; and Arena Pharmaceuticals. Key strategies undertaken by these players to increase their foothold in the market for pulmonary arterial hypertension include new product developments, collaborations, and geographical expansions. For instance, as of July 2019, United Therapeutics Corporation launched Remodulin, a medication used to treat adult patients with pulmonary arterial hypertension, wherein the Implantable System for Remodulin is expected to be launched in early 2020. It also plans to file for FDA approval in the first quarter of 2020 for the use of Tyvaso for interstitial lung disease and pulmonary fibrosis. United Therapeutics also plans to widen the market for its PAH drug, Orenitram.
Segmentations, Sub Segmentations, CAGR, & High-Level Analysis overview of Pulmonary Arterial Hypertension Market Research ReportThis report forecasts revenue growth at global, regional, and country levels and provides an analysis of latest industry trends in each of the sub-segments from 2019 to 2030. For the purpose of this study, this market research report has segmented the global pulmonary arterial hypertension market report on the basis of drug class and region:
Drug Class Outlook (Revenue, USD Million, 2019 - 2030)
- Prostacyclin and Prostacyclin Analogs
- SGC Stimulators
1 Report Overview 1.1 Study Scope 1.2 Major Manufacturers Covered in This Report 1.3 Market wsxpara3 1.3.1 Global Azithromycin Market Size Growth Rate by Type (2019-2025) 1.3.2 Oral 1.3.3 Injectables 1.3.4 Ophthalmics 1.4 wsxpara4 1.4.1 Global Azithromycin Market Share by Application (2019-2025) 1.4.2 Hospital Pharmacies 1.4.3 Retail Pharmacies 1.4.4 Online Pharmacies 1.5 Study Objectives 1.6 Years Considered2 Global Growth Trends 2.1 Global Azithromycin Market Size 2.1.1 Global Azithromycin Revenue 2014-2025 2.1.2 Global Azithromycin Sales 2014-2025 2.2 Azithromycin Growth Rate by Regions 2.2.1 Global Azithromycin Sales by Regions 2014-2019 2.2.2 Global Azithromycin Revenue by Regions 2014-2019 2.3 Industry Trends 2.3.1 Market Top Trends 2.3.2 Market Drivers3 Market Share by Manufacturers 3.1 Azithromycin Sales by Manufacturers 3.1.1 Azithromycin Sales by Manufacturers 2014-2019 3.1.2 Azithromycin Sales Market Share by Manufacturers 2014-2019 3.2 Revenue by Manufacturers 3.2.1 Azithromycin Revenue by Manufacturers (2014-2019) 3.2.2 Azithromycin Revenue Share by Manufacturers (2014-2019) 3.2.3 Global Azithromycin Market Concentration Ratio (CR5 and HHI) 3.3 Azithromycin Price by Manufacturers 3.4 Key Manufacturers Azithromycin Plants/Factories Distribution and Area Served 3.5 Date of Key Manufacturers Enter into Azithromycin Market 3.6 Key Manufacturers Azithromycin Product Offered 3.7 Mergers & Acquisitions, Expansion Plans4 Market Size by Type 4.1 Sales and Revenue for Each Type 4.1.1 Oral Sales and Revenue (2014-2019) 4.1.2 Injectables Sales and Revenue (2014-2019) 4.1.3 Ophthalmics Sales and Revenue (2014-2019) 4.2 Global Azithromycin Sales Market Share by Type 4.3 Global Azithromycin Revenue Market Share by Type 4.4 Azithromycin Price by Type5 Market Size by Application 5.1 Overview 5.2 Global Azithromycin Sales by Application6 United States 6.1 United States Azithromycin Breakdown Data by Company 6.2 United States Azithromycin Breakdown Data by Type 6.3 United States Azithromycin Breakdown Data by Application7 European Union 7.1 European Union Azithromycin Breakdown Data by Company 7.2 European Union Azithromycin Breakdown Data by Type 7.3 European Union Azithromycin Breakdown Data by Application8 China 8.1 China Azithromycin Breakdown Data by Company 8.2 China Azithromycin Breakdown Data by Type 8.3 China Azithromycin Breakdown Data by Application9 Rest of World 9.1 Rest of World Azithromycin Breakdown Data by Company 9.2 Rest of World Azithromycin Breakdown Data by Type 9.3 Rest of World Azithromycin Breakdown Data by Application 9.4 Rest of World Azithromycin Breakdown Data by Countries 9.4.1 Rest of World Azithromycin Sales by Countries 9.4.2 Rest of World Azithromycin Revenue by Countries 9.4.3 Japan 9.4.4 Korea 9.4.5 India 9.4.6 Southeast Asia10 Company Profiles 10.1 Pfizer 10.1.1 Pfizer Company Details 10.1.2 Company Description and Business Overview 10.1.3 Sales, Revenue and Market Share of Azithromycin 10.1.4 Azithromycin Product Introduction 10.1.5 Pfizer Recent Development 10.2 Akorn 10.2.1 Akorn Company Details 10.2.2 Company Description and Business Overview 10.2.3 Sales, Revenue and Market Share of Azithromycin 10.2.4 Azithromycin Product Introduction 10.2.5 Akorn Recent Development 10.3 Teva 10.3.1 Teva Company Details 10.3.2 Company Description and Business Overview 10.3.3 Sales, Revenue and Market Share of Azithromycin 10.3.4 Azithromycin Product Introduction 10.3.5 Teva Recent Development 10.4 Mylan 10.4.1 Mylan Company Details 10.4.2 Company Description and Business Overview 10.4.3 Sales, Revenue and Market Share of Azithromycin 10.4.4 Azithromycin Product Introduction 10.4.5 Mylan Recent Development 10.5 Zydus Pharmaceuticals 10.5.1 Zydus Pharmaceuticals Company Details 10.5.2 Company ... | read more...