Cell Lysis & Disruption Market Size, Share, Sector / Industry Report & Analysis 2020, & Forecast 2021-2026 (Includes Business Impact of COVID-19)

  • TBI961060
  • August 01, 2019
  • Global
  • 132 pages
  • HCCResearch
                                              

Abstract, Snapshot, Market Analysis & Market Definition: Global Cell Lysis & Disruption Market

The global cell lysis & disruption market size was valued at USD 3.23 billion in 2018 and is projected to expand at a CAGR of 8.31% during the forecast period. This growth is attributed to the higher adoption of cell lysis and disruption methods during downstream processing to manufacture bio-therapeutics and other animal-based recombinant products. Rise in investments by various government as well as private organizations in R&D related to biotechnological processes, and academics are expected to further drive the market significantly. In addition, rise in prevalence of various disorders and demand for novel therapeutics are expected to propel market growth. Expansion in the biopharmaceutical industry would also provide new growth avenues to the market, as retrieval and purification of biopharmaceuticals involves cell lysis & disruption. Moreover, the adoption of biotech processes in pharmaceutical, agricultural, and bio-services industries is expected to drive the market progress as cell lysis holds substantial importance in the course of the bioprocess. The rise in demand for efficient tumor tissue dissociation equipment has led to the development of novel products based on microfluidics. Microfluidic devices are useful in efficient dissociation of tumor tissues in single cells and thereby enhance cell recovery with respect to number and purity.

Market Segmentation, Outlook & Viewpoint: Global Cell Lysis & Disruption Market

Technique Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

Reagent-based

  • Detergent
  • Enzymatic

Physical Disruption

  • Mechanical Homogenization
  • Ultrasonic Homogenization
  • Pressure Homogenization
  • Temperature Treatments

Product Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

Instruments

  • High Pressure Homogenizers
  • Sonicator
  • French Press
  • Microfluidizer
  • Bead Mill
  • Other Instruments

Reagents & Consumables

Enzymes

  • Detergent Solutions
  • Ionic detergent
  • Nonionic detergent
  • Zwitterionic detergent

Kits & Reagents

Cell Type Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

  • Mammalian cells
  • Bacterial cells
  • Yeast/Algae/Fungi
  • Plant cells

Application Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

  • Protein Isolation
  • Downstream Processing
  • Cell Organelle Isolation
  • Nucleic Acid Isolation

End Use Market Segmentation & Outlook (Revenue, USD Million, 2014 - 2025)

  • Academic & Research Institutes
  • Hospitals & Diagnostic Labs
  • Cell Banks
  • Pharmaceutical & Biotechnology Companies

Key Players, Recent Developments & Regional Insights: Global Cell Lysis & Disruption Market

Reagents and consumables accounted for the largest share in revenue in 2018, out of which enzymes dominated the cell lysis & disruption market and are expected to grow with the faster pace in the coming years as well. Factors attributing to the estimated share include application for the selective product release, and controlled lysis as these provide biological specificity to the process. Owing to the enzyme specificity, different kits and enzymes are available for bacterial, plant, yeast, and mammalian samples. These enzymes are commercially available in a variety of forms. Major brands include but are not limited to Alfa Aesar, Millipore Sigma, MP Biochemicals LLC, Pierce Biotechnology Inc, and Promega Corporation.

Cell Type Insights

The mammalian cells segment accounted for the largest share in 2018 and is expected to remain dominant throughout the forecast period. This is because mammalian culture systems are extensively used during the bio-manufacturing of viral vaccines, therapeutic proteins, and other recombinant products. In addition, the adoption of 3D mammalian culture systems in stem cell and cancer research is anticipated boost segment growth. As the efficiency of reagents varies with the type of cell used, key companies have developed reagents that work specifically on mammalian cells. For instance, Merck Millipore provides a range of mammalian lysis reagents that are utilized for the preparation of mammalian phosphorylated, cytosolic, and nuclear proteins. Some of these products are CytoBuster protein extraction reagent, NucBuster protein extraction kit, PhosphoSafe extraction reagent, and ProteoExtract kits.

Application Insights

These methods find wide applications in protein isolation and downstream processing of biopharmaceuticals. The major application areas of protein isolation include proteomics, western blotting, and immunoprecipitation. Demand for the efficient and rapid lysis techniques that can extract proteins with minimal breakdown or oxidation is expected to fuel segment growth. Viscosity, which is resultant of the cell debris and genomic contamination is another challenge that needs to be addressed, pronouncing research in this segment. The development of advanced bioprocessing reagents and equipment that can readily complement the established disruption procedures are anticipated to propel growth in the market.

End Use Insights

Academic and research institutes held the largest market share in 2018. This is due to the presence of a large number of biotechnology institutes that explore molecular biology, and bioprocess techniques, thus using cell lysis protocols. The presence of several protocols for the tumorigenicity testing and research has led to a substantial demand for cell disruption methods in the biospecimen banking facilities. Clinical research carried out for drug development is expected to drive the growth in the years to come.

Regional Insights

North America accounted for the largest revenue share of more than 40.0% in 2018. Various government initiatives in U.S. and Canada that support molecular biology research, precision medicine, and cancer research are expected to impel the cell lysis and disruption market growth in this region. High private, as well as public, investments in target therapeutics and novel drug discovery for the treatment various complicated and rare diseases are anticipated to drive the demand further. However, Asia Pacific is poised to witness the fastest growth over the forecast period owing to the growing interest of key companies in emerging markets to reap higher profits. Cell Lysis & Disruption Market Share Insights Key companies in the market include Thermo Fisher Scientific, Inc.; Merck KGaA; F. Hoffmann-La Roche Ltd; Qiagen NV; Becton Dickinson & Company (BD); Danaher Corporation; Bio-Rad Laboratories, Inc.; Miltenyi Biotec GmbH; Claremont BioSolutions, LLC; Microfluidics International Corporation; Parr Instrument Company; BioVision, Inc.; Covaris, Inc.; and Qsonica LLC. These companies focused on novel product development and acquisitions/collaborations to enhance their market position. For instance, in February 2018, Miltenyi Biotec GmbH received EMA approval for its CliniMACS Prodigy equipment - an automated device for cell production.

Key Insights Covered: Global Cell Lysis & Disruption Market

1. North America, Europe, Asia Pacific, Middle East & Africa, Latin America market size (sales, revenue and growth rate) of Cell Lysis & Disruption industry. 2. Global major manufacturers" operating situation (sales, revenue, growth rate and gross margin) of Cell Lysis & Disruption industry. 3. Global major countries (United States, Canada, Germany, France, UK, Italy, Russia, Spain, China, Japan, Korea, India, Australia, New Zealand, Southeast Asia, Middle East, Africa, Mexico, Brazil, C. America, Chile, Peru, Colombia) market size (sales, revenue and growth rate) of Cell Lysis & Disruption industry. 4. SWOT analysis, New Project Investment Feasibility Analysis, Upstream raw materials and manufacturing equipment & Industry chain analysis of Cell Lysis & Disruption industry. 5. Global market size (sales, revenue) forecast by regions and countries from 2019 to 2024 of Cell Lysis & Disruption industry.

Research Methodology: Global Cell Lysis & Disruption Market

  • Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analyzed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more please Request a Sample Report.
  • Demand Side Primary Contributors: OEMs, Industrial Professionals, Researches, Suppliers and Distributors, Group Purchasing Organizations, Associations, Insurers, Universities, Technological Writers, Scientists, Promoters, Investors among others.
  • Supply Side Primary Contributors: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, Regulatory Affairs Managers among other

Table of Contents
Chapter 1 Executive Summary
  1.1 Market SnapshotChapter 2 Research Methodology
  2.1 Information Procurement
      2.1.1 Purchased database:
      2.1.2 HCC's internal database
      2.1.3 Secondary sources:
      2.1.4 Primary research:
      2.1.5 Details of primary research
          2.1.5.1 Data for primary interviews in North America
          2.1.5.2 Data for primary interviews in Europe
          2.1.5.3 Data for primary interviews in Asia-Pacific
          2.1.5.4 Data for primary interviews in Latin America
          2.1.5.5 Data for primary interviews in MEA
  2.2 
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